Aiyuk, back from ACL rehab, is the focal point for SF’s passing game during Kittle’s absence. His health and pace will shape weekly targets; expect him to lead SF’s WRs with steady volume and enough upside to carry fantasy rosters until Kittle returns.

Aiyuk sat out Week 2; his return will boost SF's offense and fantasy upside, especially with Purdy back

Aiyuk out, removal of one primary weapon for SF’s passing game; the offense must rely on other options and McCaffrey's usage to sustain fantasy production.

Aiyuk remains on reserve PUP with a target return around Week 6, a development that clears space in the short term and raises the risk of offense without his presence.

Aiyuk on the PUP with a knee issue; Week 2 status uncertain, complicating SF’s WR mix and target projections.